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PATENTS

Syncom employees have contributed to dozens of patents owned by clients. Syncom employees are stated as inventor in the following patents:

2011

[1,4]-BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS.

Ann Meulemans (BE), Karel Lavrijsen (BE), Marina Cools (BE), Leen Thielemans (BE), Maarten Van Geffen (BE), Erik Keller (NL) and Igor Alexnadrovich Mezine (US)

Movetis WO/2011/036204

2010

Process for preparing 5-fluoro-1H-pyrazolo [3,4-B] pyridin-3-amine and derivatives thereof.

J.M. Jimenez, P. Collier, A. Miller, J. Green, H. Gao, S. L. J. L. Hamon, A. C. Dros

Vertex US 2010/0184980 A1

2008

A method for the preparation of an enantiomerically pure benzazepine

Seerden, J.P.G.; Kemperman, G.J.

(Organon) Merck & Co. WO2008125577

2007

Enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1H-quinolin-2-one and salts thereof, useful in the treatment of cancer

Guinn, M.R.; Guhan, S.S.; Ng, K.K.; Tickner, D.L.; Ewing, M.D.; Meltz, C.N.; Li, B.; Pouwer, K.

Pfizer Inc. US7176315 B2

Synthesis of 1a-fluoro-25-hydroxy-16-23E-diene-26,27-bishomo-20-epi-cholecalciferol

Milan R. Uskokovic, Stanislaw Marczak, Ralf Loo, Marcel van der Sluis, Pawel Jankowski, Hubert Maehr

Bioxell S.P.A. WO002007022433A3

2006

Synthesis of estetrol via estrone derived steroids

Verhaar, M. T., Koch, T., Warmerdam, E. G. J.

Pantarhei US20060211669

Process for the production of optically active 3-phenylisoserine

Faber, W.; Koek, J.; Senn-Bilfinger, J.; Vries, T.

Altana Pharma AG US20060041163

2002

Novel processes for the preparation or (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol

Daugs, E.D.; Evans, J.C.; Flemming, H.-W.; Hilpert, T.H.E.; Koek, J.N.; Laskovics, F.M.; Stolz-Dunn, S.K.; Tomlinson, I.A.

Aventis Pharmaceuticals Inc. US20020151717

2001

Process for the preparation of enantiomerically enriched compounds.

W. H. J. Boesten, J. P. G. Seerden, B. de Lange, M. van der Sluis, B. Kaptein, H. M. Moody, R. M. Kellogg and Q. B. Broxterman

DSM WO 0142173

2000

Polymer electroluminescent device.

H.F.M. Schoo, R. Demandt, C.T.H.F. Liedenbaum, H. Wijnberg, W. ten Hoeve, K.J. Spoelstra.

Philips EP975710 2000

Process for the production of semi synthetic statins via novel intermediates.

T. R. Vries, H. Wijnberg, W. S. Faber, V.I. Kalkman-Agayn, M. Sibeyn.

Gist-Brocades b.v. EP971913 2000

1999

Polymer electroluminescent device.

H.F.M. Schoo, R. Demandt, C.T.H.F. Liedenbaum, H. Wijnberg, W. ten Hoeve, K.J. Spoelstra.

Philips WO9921936 1999

1-Fenyl-3-oxopropaan-1-sulfonzuren en –sulfonaten en zuivere enantiomeren daarvan.

H. Wijnberg, K.L. Pouwer, J.W. Nieuwenhuijzen, T.R. Vries.

DSM Nederlandse Octrooiaanvraag (19-8-‘99), aanvraagnummer 1012865 / NO 42870

Method for making hydroxy-25-ene vitamin D compounds.

H. Wynberg, T.R. Vries, K.L. Pouwer.

Bone Care International, Inc. WO9961417 1999

Method of preparing a thiophene-containing or furan-containing conjugated compound and precursor compound used therein.

K.H. Chmill, A.R. Brown, D.M. de Leeuw, E.E. Havinga, A. Pomp, W. ten Hoeve, H. Wijnberg.

Philips US05919951 1999

1998

Process for the separation of a mixture of enantiomers.

L. A. Hulshof, Q.B. Broxterman, T.R. Vries, H. Wijnberg, E. van Echten.

DSM EP838448 1998.

Process for the production of semi synthetic statins via novel intermediates.

T. R. Vries, H. Wijnberg, W. S. Faber, V.I. Kalkman-Agayn, M. Sibeyn.

Gist-Brocades b.v. WO9832751 1998

Method of preparing a thiophene-containing or furan-containing conjugated compound and precursor compound used therein.

K.H. Chmill, A.R. Brown, D.M. de Leeuw, E.E. Havinga, A. Pomp, W. ten Hoeve, H. Wijnberg.

Philips EP867437 1998

1997

Katalysator voor de bereiding van chirale producten in optisch actieve vorm.

H. Wijnberg, T.R. Vries, J.N. Koek, Q.B. Broxterman.

DSM Nederlandse Octrooiaanvraag (12-12-’97), aanvraagnummer 1007776.

Immunological detection of organophosphates.

W.T. Jones, H. Wynberg, W. ten Hoeve.

The Horticulture and Food Research Institute of New Zealand Limited EP629206 1994 US5677432 1997 WO9317030 1993

1993

Electrically conductive alternating copolymer and method of preparing such a copolymer.

E.E. Havinga, W. ten Hoeve, H. Wijnberg.

Philips EP551938 1993 US5380807 1995

Method of preparing aryl(homo)piperazines.

W. ten Hoeve, J.R.G. Thiecke, H. Wynberg, C.G. Kruse.

Duphar EP556889 1993 US5463050 1995

1992

Method for the photochemical isomerization of organic compounds under the influence of a photosensitizer.

L.F. Pauli, A. Dufourny, R.B. Koolstra, H. Wynberg, W. ten Hoeve.

Duphar EP454204 1992 US5252191 1993

1991

Pyridinium hydrochloride metoclopramide demethylation.

H. Wynberg, E. van Echten, W. ten Hoeve.

Marion Merrell Dow Inc. EP431561 1991

1990

Hydroxylated ene ketones, acetylenic Grignards and hydroxylated yne ketones therefrom.

H. Wynberg, G.A. Barf, D.R. Borcherding, W. ten Hoeve, J.N. Koek.

Marion Merrell Dow Inc. EP414180 1991 US04973756 1990

Processes for the preparation of (R)-.agr.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.

J.N. Koek + 20 HMR-people.

Hoechst Marion Roussel Deutschland GMBH. WO9946245 1999

Nonlinear optical compound, nonlinear optical medium, method of manufacturing a nonlinear optical medium and device for doubling the frequency of a light wave.

E.W. Meijer, W. ten Hoeve, S. Nijhuis, G.L.J.A. Rikken, E.E. Havinga.

Philips EP396172 1990

1989

Improved resolution of 3-(4-methoxyphenyl)glycidic acid with in situ conversion to alkyl esters.

H. Wynberg and W. ten Hoeve.

Marion Laboratories, Inc. EP342903 1989

Resolution of 3-(4-methoxyphenyl)glycidic acid with in situ conversion to alkyl esters.

H. Wynberg and W. ten Hoeve.

Marion Laboratories, Inc. US4885375 1989

Method of manufacturing conductive heterocyclic polymers, new heterocyclic conductive polymers, new intermediate products for the preparation of the polymers, and synthesis of the intermediate products.

K.L. Pouwer, T.R. Vries, E.E. Havinga, E.W. Meijer, H. Wijnberg.

Philips EP340826 1989

Dioxaphosphorinanes, their preparation and use for resolving optically active compounds.

W. ten Hoeve and H. Wijnberg.

Syncom US4814477 1989

1986

Dioxaphosphorinanes, their preparation and use for resolving optically active compounds.

W. ten Hoeve and H. Wijnberg.

Syncom EP180276 1986