MEDICINAL CHEMISTRY SERVICE

Syncom has a proven track record of more than 20 years in assisting leading pharma and biotechnology companies within their hit-to-lead optimization process in numerous therapeutic areas. Our well-known problem solving capacity in organic chemistry has not only resulted in high quality compounds for (pre)clinical studies but also in improved synthetic routes amenable for scaling up.

A fast interpretation of biological and SAR data, the awareness of essential physicochemical parameters in the optimization process and our chemical expertise and state-of-the-art chemical infrastructure result in high quality compounds in a minimum amount of time. One of our research programs is dedicated to hit-to-lead optimization for versatile drug delivery platform for inflammatory diseases and cancer.

Services offered are:

• Design Synthetic Strategy, Route Scouting and Early Process Development for Hits
• Library Preparation
• Computational Chemistry (SYBYL)
• Interpretation of SAR Data and Subsequent (Chemical) Optimization
• Route Optimization for Scale-up and GMP Production